Ayurveda has two objectives namely preservation of health and treatment of diseases. There are three types of modalities for the treatment of diseases as per Ayurvedic classics; namely Daiv Vyapasraya, Yukti Vyapaksray and Satvavajay. The main procedure concerned with the medical treatment is Yukti Vyapashray which compises of Samshodhana and samshaman therapy used for the preservation of health as well as to cure the disease. The samshodhana is concerned with the five evacuatory measures known as Panchkarma. The basic aim of using Panchkarma is preservation of health as well to eliminate the aggravated doshas so that one can get the desired effect of drugs. It is considered that by use of samshodhana we can cure half of the medical diseases. This concept has become more scientific in present era in which the society is facing different types of diseases related to environmental factors as well as their occupation. The only remedy seems to be more practical is samshodhana, by which we can eliminate the absorbed poisonous material from the body. Mechanisms underlying these effects may include free-radical scavenging effects, immune system modulation, brain neurotransmitter modulation, and hormonal effects. So the Panchkarma therapy should be used not only to cure the diseases but also for the conservation of the health in this era.